Perception of concept of bronchopulmonary dysplasia into neurodevelopmental outcomes

Understanding the short and long-term pulmonary and neurologic outcomes of neonates with bronchopulmonary dysplasia (BPD) is important in neonatal care for low-birth-weight infants. Different criteria for BPD may have different associations with long-term outcomes. Currently, two criteria for diagnosing BPD have been proposed by the NIH (2001) and NRN (2019) for preterm infants at a postmenstrual age (PMA) of 36 weeks. We investigated which BPD definition best predicts long-term outcomes. Korean nationwide data for preterm infants born between 24 +0 and < 32 +0 weeks gestation from were collected. For long-term outcomes, severity based on the NRN criteria was significantly related to neurodevelopmental impairment (NDI) in a univariate analysis after other risk factors were controlled. For the admission rate for respiratory disorder, grade 3 BPD of the NRN criteria had the highest specificity (96%), negative predictive value (86%), and accuracy (83%). For predicting NDI at the 18–24 month follow-up, grade 3 BPD of the NRN criteria had the best specificity (98%), positive (64%) and negative (79%) predictive values, and accuracy (78%) while NIH severe BPD had the highest sensitivity (60%). The NRN definition was more strongly associated with poor 2-year developmental outcomes. BPD diagnosed by NRN definitions might better identify infants at high risk for NDI.


Bronchopulmonary dysplasia (BPD) was a primary side-effect during the suprisingly low beginning lbs babies (VLBWIs). More severe BPD was associated with a greater likelihood of developmental disability and you may shorter pulmonary form 1,2,3 . Medical course of the illness, like the importance of rehospitalization and neurodevelopmental disability, was a noted question one of mothers and healthcare team 4 . Finding out how situation seriousness is associated with developmental impede and you may readmissions can help publication future research and you can high quality update efforts to minimize the burden in the infection.

BPD was first defined of the Northway ainsi que al. 5 over 50 years back; but not, during the 2001, brand new National Institute out of Child Wellness (NIH) changed the newest categorical meanings away from BPD. Recently, inter-center variability when you look at the fresh air administration and you can nasal cannula circulate, and the usage of noninvasive venting, is also bias this new NIH group of BPD presence and you will severity. This means that, these widely used standards is almost certainly not acceptable for the current logical problem and/or prediction regarding long-title ramifications of modern-day VLBWIs 6,seven . In accordance with it difference, Jensen ainsi que al. 8 proposed another definition of BPD that finest forecast early youth morbidity and you will categorized situation seriousness with regards to the mode out-of breathing help, no matter what usage of supplemental outdoors. It definition are modified so you can more accurately expect respiratory readmission and you may developmental waits when you look at the a beneficial U.S.-created people.

And therefore, we lined up to determine and this definition of BPD at a great PMA from thirty-six months are best suited getting predicting a lot of time-identity neonatal consequences, like pulmonary and you will neurologic effects, measured within 18–two years fixed years (CA), inside the a multicenter cohort examination of VLBWIs in line with the all over the country Korean Neonatal System (KNN) registry.

Overall performance

A maximum of 8294 babies created between twenty-four +0 weeks and you can 29 +6 months GA was basically joined into KNN, Once leaving out babies, 2889 VLBWIs remained; included in this, 1849 (64.0%) got done go after-up suggestions available at Ca 18–24 months, along with respiratory readmission and you may developmental outcomes (Fig. 1). Of those 1849 VLBWIs, 1221 (66.0%) got BPD with respect to the NIH meaning, and 665 kids (36%) which have light BPD, 184 infants (10%) which have average BPD, and you can 372 infants (19%) having serious BPD. In contrast 555 kids (30%) had BPD according to the NRN meaning, and 186 kids (10%) having stages 1 BPD, 303 infants (16%) having grade dos BPD, and you can 66 children (4%) having level step three BPD (Desk 1).

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